Thursday, February 28, 2013

Cell movement explained by molecular recycling

Feb. 28, 2013 ? Scientists at The University of Manchester have identified the method by which cells control the recycling of molecules, a process that is essential for them to move. The discovery provides researchers with a better understanding of how our bodies heal wounds.

Working under Professor Martin Humphries, the Dean of the Faculty of Life Sciences, Dr Mark Morgan and his team at the Wellcome Trust Centre for Cell Matrix Research studied the role of integrins. These molecules are able to grab hold of the fibres surrounding the cell, like hands, allowing the cell to drag its self along. However, there are several types of integrin on the cell surface and they all have different properties which affect how quickly the cell can move.

Once they have been used by the cell, integrins are moved from the surface to a store inside the cell. When the time is right they are recycled back to the cell surface where they can bind with the surrounding fibres once again.

What the team uncovered is the method by which cells dynamically control the type of integrins that are recycled. They found that another molecule on the surface of the cell, called syndecan-4, is able to detect and interpret subtle changes in the cell's surroundings to decide how it should respond. By regulating where and when the different integrins are delivered to the cell surface, syndecan-4 precisely regulates cell movement and exploration.

Dr Morgan says: "Syndecan-4 plays a critical role in regulating wound healing, so ultimately, we hope that this work will inform the development of novel therapeutic strategies to improve wound healing."

Most cells in the body are able to crawl through the dense network of fibres that surround them. This migration process is essential for repairing wounds, tracking down infection and maintaining tissue function.

In order for a cell to move efficiently, it needs to precisely control which integrins are able to bind to the fibres. At certain times and places they need to bind strongly, whereas at other points they need to bind more weakly, and only when these processes are regulated appropriately can a cell migrate properly.

By studying the movement of fibroblast cells using sophisticated imaging techniques, Dr Morgan and the team identified the role of Syndecan-4. They found that it decodes the vast array of signals outside the cell and functions as a molecular switch to dictate whether the strong or weak binding integrins are recycled.

Dr Morgan explains: "When we changed the way Syndecan-4 senses the environment outside the cell, we were able to alter the way that it transmits signals into the cell and control integrin recycling. By manipulating the molecules in this way we found that we could either force the cells to move in a fast forward motion or stop altogether."

Their findings have been published in the journal Developmental Cell.

The next step will be to investigate how Syndecan-4 can be manipulated to control cell movement with a view to developing novel therapeutic strategies to improve wound healing. It will also be important to test whether this mechanism is involved in tumour progression and metastasis as disruptions in cell movement are often seen in cancer, as well as in vascular disorders and chronic inflammatory disease.

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The above story is reprinted from materials provided by University of Manchester, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Mark?R. Morgan, Hellyeh Hamidi, Mark?D. Bass, Stacey Warwood, Christoph Ballestrem, Martin?J. Humphries. Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling. Developmental Cell, 2013; DOI: 10.1016/j.devcel.2013.01.027

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/Q-d8Ol5EJkU/130228124045.htm

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First lady announces effort to help kids exercise

(AP) ? Imagine students learning their ABCs while dancing, or memorizing multiplication tables while doing jumping jacks.

Some schools are using both methods of instruction, and Michelle Obama would like to see more of them use creative ways to help students get the recommended hour of daily exercise.

In Chicago on Thursday, the first lady was announcing a new partnership to help schools do just that. It starts with a new website, letsmoveschools.org , where school officials can sign up to get started.

The effort is the newest part of Mrs. Obama's 3-year-old campaign against childhood obesity, known as "Let's Move."

Mrs. Obama is on the final day of a two-day tour to promote "Let's Move," with appearances Thursday in Chicago and Springfield, Mo.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-02-28-Michelle%20Obama/id-e57db04c832d4588a2cc4b8868d0ed77

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Sunday, February 24, 2013

Microsoft Victimized by Cyber Attack


Software giant Microsoft has become the latest victim of a shameless and malicious computer hacking, according to a CNN report.

The report claim that Microsoft general manager Matt Thomlinson has admitted to such an attack to the software company by saying, "As reported by Facebook and Apple, Microsoft can confirm that we also recently experienced a similar security intrusion."

Thomlinson went on further to say "During our investigation, we found a small number of computers, including some in our Mac business unit, that were infected by malicious software using techniques similar to those documented by other organizations."

Microsoft gave few other details about the hacking incident, but the company said it had "found no evidence that any customer data has been stolen in the cyber attack."

In addition, Thomlinson said Microsoft was being targeted by "determined and persistent adversaries," though he didn't specify who those were, but there's also an NBC news report linking the recent attacks on the Internet on the U.S. government and American private companies to hackers working for the military based in China.

Meanwhile, a Business Insider report has shared an article on how the people can protect themselves against the "alleged" Chinese hackers. You may also want to read that site's report here.

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Source: http://feeds09.technorati.com/~r/trarticles/~3/Ubk1ehaFIR8/

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5 live Sport: Premier League Football 2012-13: QPR v Manchester United

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Source: http://www.bbc.co.uk/iplayer/episode/b01qwcxv/5_live_Sport_Premier_League_Football_201213_QPR_v_Manchester_United/

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Samsung Galaxy S4 to Use Snapdragon 600 Quad-core Processor

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Source: www.ibtimes.com --- Saturday, February 23, 2013
Qualcomm Snapdragon 600 quad-core processor to be used instead of Exynos 5 octa-core. ...

Source: http://www.ibtimes.comhttp:0//www.ibtimes.co.in/articles/438619/20130223/galaxys4-snapdragon600-quadcore-processor-lte-exynos5-galaxy.htm

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Sony PS4: All-you-can-eat game subscriptions may be in the works

The Sony PS4 console may house a premium subscription service allowing members to play as many games as they want for a monthly fee, according to the president of Sony Worldwide Studios.

Shuhei Yoshida said Sony has many options with regards to subscription platforms, thanks to the acquisition of Gaikai - the cloud-gaming company that will power and pioneer the PS4's online offerings.

Some observers had expected Sony to reveal a Netflix-for-gamers style service at Tuesday's launch event, but for now that's a 'dream' dependent on digital content flourishing on the console, Yoshida-san said.

He told The Guardian: "As more and more services and contents become available digitally, we'll have more of an option to create attractive packages. So hypothetically we can look at different models ? like a cable TV company. We could have gold, silver or platinum levels of membership, something like that.

"We can do subscription services when we have more content ? especially now that we have the Gaikai technology available. With one subscription you have access to thousands of games ? that's our dream."

Hardware isn't finished yet

Meanwhile Yoshida-san is the latest voice to chime in on why Sony did not reveal the new PlayStation hardware at Wednesday night's PS4 launch event in New York City.

Some Sony bosses have claimed the company wanted to leave something to show off at a later date, so we wouldn't get bored between now and the Holiday 2013 release date, while SCEA gaffer Jack Tretton claimed Sony had made a 'conscious decision' not to show it off.

This latest explanation might be a little closer to the mark.

"We have not finalised the hardware yet and decided not to try to get it finished in time," Yoshida-san said.

Via Guardian

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Alaska lawmaker wants $100 bounty on sea otters

Sea otter bounty: An Alaska state senator says sea otters are a growing threat to shellfish, including crabs. On Wednesday, he introduced legislation that would have the state pay $100 for each sea otter lawfully killed under the federal Marine Mammal Protection Act.

By Becky Bohrer,?Associated Press / February 21, 2013

A sea otter in Kachemak Bay, Alaska. Alaska state senator Bert Stedman, (R) of Sitka, is proposing a $100 bounty on sea otters.

(AP Photo/Laura Rauch, File)

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An Alaska state senator is proposing a bounty on sea otters, the cute little marine mammals often seen by tourists swimming on their backs between cruise ships, sometimes munching on a fresh crab or clams.

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Sen. Bert Stedman, R-Sitka, sees the furry-faced critters as a growing threat to shellfish beds, particularly in southeast Alaska, where he is from. On Wednesday, he introduced legislation that would have the state pay $100 for each sea otter lawfully killed under the federal Marine Mammal Protection Act.

"We're not talking eradication. We're talking slowing the population growth," he said. "In my opinion, we're not going to get any help from the federal government."

Even if the bill were to pass, it would be unenforceable under the federal law, said Bruce Woods, a spokesman for the U.S. Fish and Wildlife Service. States cannot enforce laws or regulations related to the taking of any marine mammal under the law unless the Interior secretary transfers conservation and management authority to that state. That hasn't happened.

Stedman said part of what he is trying to do is begin a discussion on the issue and send a message to the feds that something needs to be done. "Clearly, it's a problem," he said, "and it's going to get worse."

There are three sea otter populations in Alaska, in southwest, south-central and southeast Alaska, whose numbers total an estimated 98,000. The number for the southwest population, listed as threatened under the Endangered Species Act, is the largest, at 55,000, but the latest estimate is more than 10 years old and the population is thought to be in decline, Woods said. Population estimates for the other regions are from 2010-2011. Both those populations are growing, he said.

Since their reintroduction to southeast Alaska by the state in the 1960s, after being virtually wiped out during the fur trade era, the number of sea otters in that region has grown to about 25,000, Woods said. The Marine Mammal Protection Act transferred management authority to Fish and Wildlife in 1972.

Under the federal law, only Alaska Natives can hunt sea otters in Alaska; there is no hunting season and no bag limit, but there are prohibitions on wasteful take ? that is, killing sea otters for the sake of killing them, Woods said. At least 840 sea otters were taken for subsistence reasons last year, the highest since 1993, and not surprising given the growing size of the population, wildlife biologist Verena Gill with Fish and Wildlife said.

Fisherman Ladd Norheim of the southeast Alaska community of Petersburg said the sea otters are "decimating" Dungeness crab stocks and would like to see some kind of management. He said half the area he used to fish for Dungeness in southeast Alaska is gone. Three years ago, he said there were 21 Dungeness boats over by Kake. Last year, he said there were two, and one left.

"What strikes me funny: I'm fishing crab right now, and if a crab stock gets low or something or ... any fishery, they shut us off or close us down to protect a crab or a fish. Yet when a sea otter comes in and absolutely decimates an area, they don't do anything about it," he said Thursday. "They just say, 'Oh, they're warm and fuzzy and cute.' Well, I'm pretty warm and fuzzy and cute, too, but I don't totally wipe anything out.

"I mean, crab have rights. Clams have rights. Where do sea otters come out being so holy?" he said.

Woods said he understands the frustrations.

"But our management has to be driven by science," he said. And questions remain about where the population is in terms of its establishment and carrying capacity, and what exact impacts it is having on prey species, like crabs or clams, he said. The agency is working with the University of Alaska Fairbanks to study those issues.

___

Follow Becky Bohrer on Twitter at http://twitter.com/beckybohrerap .

Copyright 2013 The Associated Press.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/2G2Xv0-LA4U/Alaska-lawmaker-wants-100-bounty-on-sea-otters

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Photo: A house damaged by the 'mini tornado' near Sydney, Australia - @9NewsSyd